NEUROLOGIST RECOMMENDED5.

Targeted Nutrition to slowCognitive Decline and BrainShrinkage

Improve Brain Health, Memory, Focus&Concentration

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When Little Slips Start Adding Up

Everyone forgets things now and then — a name, a date, where you left your keys. But when those slips start to happen more often, or daily life feels a little harder, it might be worth bringing up with your healthcare provider. Some additional signs you may notice include:

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    Missing appointments often

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    Struggling to find words

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    Frequently losing things

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    Losing train of thought

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    Having trouble deciding

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    Getting lost in familiar places

    Dual Action Formula

    Targeted nutrition for Mild Cognitive Impairment (MCI).

    Improves

    Brain Health

    Cerefolin Brain Wellness™ helps support overall brain function by providing essential nutrients that aid in reducing harmful homocysteine levels, which can negatively impact brain health.3*

    Memory & Focus

    Individuals taking Cerefolin Brain Wellness™ showed improvement in memory and ability to focus on daily activities.4*

    Concentration

    Cerefolin Brain Wellness™ helped people maintain attention and stay on task, which are essential for completing daily tasks and decision-making processes.4*
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    Slows

    Cognitive Decline

    Long-term use of Cerefolin Brain Wellness™ was associated with a significantly slower rate of cognitive decline, especially in individuals with mild cognitive impairment.2*

    Brain Atrophy

    Research shows that people with mild cognitive impairment (MCI) and elevated homocysteine who took Cerefolin Brain Wellness™ experienced slower brain shrinkage — helping support memory, thinking skills, and overall brain health.1*

    Trust in the Results

    Neurologists recommend Cerefolin Brain Wellness™*. Starting early can help protect your brain cells, slow the loss of brain function, and improve your overall quality of life.1-3

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    Clinically Proven To

    Slow the rate of brain shrinkage by 11.2x1*

    Strong Loyalty

    94% who used product for 90 days said they planned to continue4*

    Free From

    Gluten, dyes, sugar, sodium, caffeine, preservatives, GMOs, titanium dioxide and major food allergens*

    What people are saying§||*

    • -Tessa

      "l am feeling improvementsfrom taking CerefolinNAC®*."
      "We have many good yearsahead of us to enjoy the active
      lives we lead."

    • -George

      Those things really work." “i'm
      not going to the refrigerator
      looking for ketchup and
      forgetting what l went to it for."

    • -Monica

      "I believe that CerefolinNAC@:
      helped me tremendously with
      my day to day thinking."

    • -Tressie

      "i'm very appreciative of your
      wonderful service and also yourgreat product."“lrecommend it
      to everybody."

    • - Roland

      'This has been a night and day
      difference. l feel like myself
      again."

    • - Laura

      “l am doing much better.

    • -Cecelia

      "l used to forget things a lot, butstill a little, but not like before.Before it was terrible.l wouldeven cry.l would get frustratedbecause my forgetfulness was
      so bad."

    • Column

      "[My husband] was almost 97and he used that for many,many, years and his mind wassharp as could be so l believe in
      it"

      For Alzheimer’s & Brain Awareness Month, Take Time to Understand & Protect Your Brain Health

      June is Alzheimer’s & Brain Awareness Month—a time to spotlight the importance of brain health and support individuals facing cognitive challenges.

      Why Cerefolin Brain Wellness™?

      More than just memory support, dual-action Cerefolin Brain Wellness™ slows cognitive decline and brain shrinkage while also improving brain health, memory, focus and concentration.1-4

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      This product is neurologist-recommended* targeted nutrition your body cannot get from diet alone. Previously sold by prescription-only, Cerefolin Brain Wellness™* is specially formulated to help people address mild cognitive impairment and high homocysteine blood levels. One caplet a day can help preserve mental sharpness and improve your overall quality of life.

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      4 Reasons to Choose Cerefolin Brain Wellness™

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        Neurologist Recommended*

        This dual-action targeted nutrition product helps lower homocysteine levels.1-2Your body needs this amino acid, but high levels of homocysteine increase risk of MCI.
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        Slows Brain Shrinkage

        In a clinical study, patients with high homocysteine levels taking Cerefolin Brain Wellness™* showed an 11.2 times slower rate of brain atrophy compared to those not taking it.1
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        Long-Term Results

        Cerefolin Brain Wellness™* is backed by an MRI study and up to 7 years of clinical data from the same patients, showing long-term use may help slow cognitive decline and maintain essential brain function.1, 3
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        Clinically Tested Ingredients

        High-quality ingredients have been clinically tested to ensure safety and effectiveness of our product.

        Cerefolin Brain Wellness™ Is

        • Major Allergen Free*

        • Caffeine Free

        • Dye Free

        • Gluten Free

        • Non-GMO

        • Preservative Free

        • Sodium Free

        • Sugar Free

        • Titanium Dioxide Free

        • Vegan

          Brain Boosting Antioxidant Power

          Active Folate
          L-Methylfolate is the active form of folate that supports memory and focus-related neurotransmitter production, while improving brain metabolism.
          Vitamin B12
          Methylcobalamin (vitamin B12) boosts energy production to support overall brain function.
          NAC
          N-Acetyl-l-cysteine (NAC) contributes to brain health by reducing oxidative stress.

          Supporting Your Brain Today For a Better Tomorrow

          Memory problems, difficulty focusing, and stumbling over words can be startling. No one wants to lose brain function, especially when you still feel able and active otherwise. Starting Cerefolin Brain Wellness™ early can help protect your brain cells, slow the loss of brain function, and improve your overall quality of life.1-4*

          FAQS

          CerefolinNAC® Name Change

          What happened to CerefolinNAC® that my doctor prescribed?

          CerefolinNAC® was replaced by Cerefolin Brain Wellness™, which is the same trusted and effective product that is now free from major allergens (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame and soy), dyes and colorants. We changed the name because we made the product more accessible to those who want or need it. It’s now available online in 30 day and 60 day supply packages without a prescription. Because we know healthcare providers will continue prescribing Cerefolin Brain Wellness™ to their patients, too, it’s also available by prescription in a 90 day supply.

          How is Cerefolin Brain Wellness™ different from CerefolinNAC®?

          Cerefolin Brain Wellness™, previously known and studied as CerefolinNAC®, is the same trusted and effective product that is now free from, dyes, colorants, and major allergens (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame and soy). Now you can get the benefits without a prescription or, if needed, with a prescription through your healthcare provider.

          Targeted Nutrition

          What is targeted nutrition?

          Targeted nutrition products are medical foods specially formulated with active (bioavailable) nutrients you cannot get through diet alone to meet the distinct nutritional requirements to address a certain condition—in this case, Mild Cognitive Impairment (MCI). A medical food should be taken under medical supervision.

          What is Cerefolin Brain Wellness™ and what are the ingredients?

          Cerefolin Brain Wellness™ is a targeted nutrition product for use under medical supervision for the clinical dietary management of Mild Cognitive Impairment in patients with hyperhomocysteinemia (high homocysteine blood levels). It is specially formulated to meet the distinctive nutritional requirements for this condition.
          Dietary ingredients include: 6 mg of L-Methylfolate calcium (active folate), 2 mg Methylcobalamin (Vitamin B12), and 600 mg N-Acetyl-l-cysteine (NAC). All ingredients: N-Acetyl-l-cysteine (NAC), Microcrystalline Cellulose and Silicon Dioxide, Hypromellose, L-Methylfolate Calcium, Magnesium Stearate (NF, Vegetable Source), Methylcobalamin.
          Manufactured in the USA with high-quality ingredients sourced both in the U.S. and globall

          What is active folate and why is It important for brain health?

          L-Methylfolate is an active folate, which means your body can absorb it and make use of it without having to take additional steps to break it down and activate it. L-Methylfolate may affect certain chemicals in the brain important for memory, cognitive function and brain health. It helps address underlying imbalances to help you retain your ability to learn, understand, and remember.

          How Cerefolin Brain Wellness™ Works

          How does Cerefolin Brain Wellness™ work?

          Cerefolin Brain Wellness™ works by providing essential nutrients for brain health, that help to manage memory loss symptoms. The three nutrients include:
          • L-Methylfolate, the active form of folate that supports memory and focus-related neurotransmitter production, while improving brain metabolism.5
          • N-Acetyl-l-cysteine (NAC) contributes to brain health by reducing oxidative stress. 10
          • Methylcobalamin boosts energy production to support overall brain function.9
          These ingredients efficiently decrease homocysteine levels, which over time can help limit blood vessel damage and brain shrinkage linked to cognitive declin

          What are the benefits of a “dual-action” formula?

          The ingredients in Cerefolin Brain Wellness™ are formulated for dual action in the brain: 
          1. Improves brain health, memory, focus and concentration
          2. Slows cognitive decline and brain atrophy

          How is Cerefolin Brain Wellness™ different from other product options?

          Cerefolin Brain Wellness™ began as a targeted nutrition product prescribed by neurologists and is recommended by neurologists to address the early signs of mild cognitive decline, protecting memory and cognitive function*. The ingredients in Cerefolin Brain Wellness™ are different from the ingredients found in most folic acid products.  Its formula provides the body with already-active folate (which means it can be absorbed and immediately used by the body because it doesn’t need to be broken down or activated), N-Acetyl-l-cysteine, and B12 that the body needs to address symptoms of Mild Cognitive Impairment (MCI). Most folic acid products need to be broken down in the body before the folate can be used, and many people may not be able to fully complete this activation.

          Does Cerefolin Brain Wellness™ preserve memory and slow cognitive decline?

          The dietary ingredients in Cerefolin Brain Wellness™ have been shown in multiple studies to support memory, brain health and cognitive function*. In a real-world study with patients with high homocysteine levels and memory loss, Cerefolin Brain Wellness™ delayed brain atrophy up to 11.2 times better than patients not taking Cerefolin Brain Wellness™ and significantly improved quality of life scores. Other clinical studies showed Cerefolin Brain Wellness™ supports memory retention and executive function (thinking, decision making), helping patients maintain focus and perform memory-related tasks.1-4

          Using Cerefolin Brain Wellness™

          Can I buy Cerefolin Brain Wellness™ without a prescription?

          Yes, you can buy Cerefolin Brain Wellness™ without a prescription in a 30 and 60 day supply. However, you should inform your healthcare provider as targeted nutrition is meant to be used under medical supervision. See our product page for details.

          Do I need to tell my doctor I’m taking Cerefolin Brain Wellness™?

          Yes. Cerefolin Brain Wellness™ is targeted nutrition for use under medical supervision. While you can buy it directly, you should tell your healthcare provider you are using it and follow their advice.

          How do I know if Cerefolin Brain Wellness™ can help me?

          If you are noticing changes in memory or thinking and are concerned about mild cognitive decline, talk to your healthcare provider and try Cerefolin Brain Wellness™. Cerefolin Brain Wellness™ is targeted nutrition that can address certain nutrient imbalances in the brain and help you retain your ability to learn, remember, and understand, and protect this cognitive function longer than going without it. Everyone is different, so results can vary and it will take some time to work.

          How long does it take to notice results?

          Some people notice results in as little as 45 days, but timing and results vary. We typically recommend people take it for at least 12 weeks to start noticing results.

          How long can I take Cerefolin Brain Wellness™?

          Long-term use of Cerefolin Brain Wellness™ can continue to help support your cognitive health. Cerefolin Brain Wellness™ is supported with over 7 years of clinical data. As with any medical food, talk with your healthcare provider first before stopping Cerefolin Brain Wellness™*.

          Can I take Cerefolin Brain Wellness™ with other medications or supplements?

          It is typically safe to take Cerefolin Brain Wellness™ with other cognitive therapies and other medications, but it is always smart to talk to your healthcare provider to be sure.

          Does Cerefolin Brain Wellness™ have any contraindications?

          Cerefolin Brain Wellness™ is contraindicated in patients with known hypersensitivity to any of the components contained in this product.

          Clinical Data & Manufacturing

          Other brands say “clinically proven,” so what makes Cerefolin Brain Wellness™ different?

          The ingredients in Cerefolin Brain Wellness™ have been tested in many clinical studies. In addition, we have clinical data on patients we have followed for over 7 years, plus an MRI study that showed using Cerefolin Brain Wellness™ for over 2 years showed a rate of brain shrinkage 11.2 times slower than those not taking it.1*Our healthcare provider pages provide more detail.

          What are some of the benefits of Cerefolin Brain Wellness™ as supported by clinical studies?

          Improves Brain Health, Memory, Focus and Concentration:

          • Supports acetylcholine and glutathione production5, 10, 11
          • Enhances vascular blood flow and cellular regeneration9, 12-14
          • Lowers elevated homocysteine levels1, 2
          • Clinical studies show Cerefolin Brain Wellness™* supports memory retention and executive function, helping patients maintain focus and perform memory-related tasks.2-4
          • In a clinical study, people taking Cerefolin Brain Wellness™* for at least one year can significantly slow the progression of memory decline.2, 3

          Slows Cognitive Decline & Brain Atrophy:

          • Cerefolin Brain Wellness™* has been shown to slow the progression of cognitive decline, helping patients maintain essential cognitive function longer.2
          • A study revealed Cerefolin Brain Wellness™* can slow brain atrophy by up to 11.2 times compared to patients not taking Cerefolin Brain Wellness™, preserving brain health in those at risk of cognitive decline.1

          Where is Cerefolin Brain Wellness™ manufactured?

          Cerefolin Brain Wellness™ is manufactured and distributed by Alfasigma USA, Inc. in Shreveport, LA.

          Mild Cognitive Impairment (MCI)

          What is Mild Cognitive Impairment (MCI)?

          Mild Cognitive Impairment, also called MCI, is a condition in which some older adults have more memory loss or thinking problems than other people their age. They may notice these changes, but they typically are not bad enough to affect normal everyday activities.

          What are the signs of Mild Cognitive Impairment?

          Forgetting things here and there can be a normal part of aging, but symptoms of MCI typically happen more often but do not yet impact everday activities. MCI symptoms include:

          • Forgetting to go to events and appointments
          • Losing things often
          • Having trouble coming up with words more than other people your age
          • Losing your train of thought or having difficulty following a conversation
          • Finding it hard to make decisions or follow instructions
          • Getting lost in familiar surroundings

          How do I know if I or my loved one has MCI?

          If you’re noticing changes in memory or thinking in yourself or in a loved one, it’s time to talk to a healthcare provider. They can perform tests—such as testing to see if you have elevated homocysteine levels—to assess whether you have MCI or another condition. Sometimes other health issues can cause similar memory or thinking problems, so it’s always good to get checked out, if you are noticing changes.